IHMRI affiliation

Theme:Diagnostics and therapeutics
Level:IHMRI Senior Fellow

Research focus

Distinguished Professor Dixon’s primary research interest is to uncover the fundamental chemical principles that underpin the operations and functions of dynamic multi-protein machines. He uses the bacterial multi-protein DNA replication apparatus (the replisome) as a model system to understand these principles. To achieve this requires multidisplinary approaches: Dixon combines macromolecular structure determination (primarily X-ray crystallography and cryo-electron microscopy, but also other techniques) with functional DNA replication assays (single-molecule, bulk phase replication assays, as well as other biophysical measurements). Since replisomes are excellent targets for development of new antibacterial drugs to combat the tide of antimicrobial drug resistance, Dixon also leads a translational research program in drug development.

Research projects

Publications and funding

Other roles

  • Fellow of the Royal Society of New South Wales
  • Director, Centre for Medical & Molecular Bioscience (CMMB), UOW

IHMRI research team

Research fellows

Dr Slobodan Jergic T: +61 2 4221 5122 | E: jergic@uow.edu.au
Dr Zhi-Qiang Xu T: +61 2 4221 5122 | zhiqiang@uow.edu.au

Masters students

Alok Prahan Structure of the clamp loader complex