Distinguished Professor Nick Dixon

Distinguished Professor Dixon’s primary research interest is to uncover the fundamental chemical principles that underpin the operations and functions of dynamic multi-protein machines. He uses the bacterial multi-protein DNA replication apparatus (the replisome) as a model system to understand these principles. To achieve this requires multidisplinary approaches: Dixon combines macromolecular structure determination (primarily X-ray crystallography and cryo-electron microscopy, but also other techniques) with functional DNA replication assays (single-molecule, bulk phase replication assays, as well as other biophysical measurements). Since replisomes are excellent targets for development of new antibacterial drugs to combat the tide of antimicrobial drug resistance, Dixon also leads a translational research program in drug development.

• Molecular Interactions with an Antibiotic Target in DNA Replication

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• Fellow of the Royal Society of New South Wales
• Director, Centre for Medical & Molecular Bioscience (CMMB), UOW