IHMRI affiliation

Theme:Diagnostics and therapeutics
Level:IHMRI Senior Fellow

Research focus

  • Lipidomics
  • Vision science
  • Ageing
Research projects

Developing next generation technologies for unmasking the lipidome

Recent discoveries suggest that the number and structural variety of lipids in nature may be far greater than previously imagined. This complexity arises from the presence of structurally similar, but functionally distinct, lipid isomers that are not readily distinguished using current lipidomics technologies. We aim to develop unique instrumentation that combines ion-mobility and mass spectrometry; enabling the rapid separation,
identification and quantification of isomeric lipids.

Lead institution: University of Wollongong
Partner institution: Queensland University of Technology

Alterations to Lipid Pathways in Huntington’s Disease

Summary: Disturbances to cholesterol and sphingolipid metabolism have been identified in Huntington’s disease (HD), and these disturbances are also involved in similar neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. In this study we aim to further characterise these alterations in cholesterol and sphingolipid metabolism and also determine the extent to which other lipid classes are implicated in an attempt to identify new treatment targets.

Lead institution: University of Wollongong
Partner institution: University of New South Wales

Publications and funding

IHMRI research team

Research fellows

Dr Michael Friedrich T: +61 2 4298 1564 | E: michaelf@uow.edu.au

PhD candidates

Jo Ann Seng Charactersing Age-related Changes in the Human Lens Sphingolipidome
Nicholas Martin Long live the queen: influence of membrane phospholipids on longevity of honey bees
Ayedh Alqarni Validation to Assess Omega-3 Status Using an Automated System and its Application in Clinical Research