The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function.
The project is significant because the unique combination of skills including synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics which aim to result in a major shift in the understanding of this layer.
Australian Research Council
2014 – 2017 (extended into 2018)
The University of New South Wales
Allergan Inc; University of Western Sydney; University of Wollongong