Sphingolipids are a class of lipid metabolites that have a variety of functions within cells. It has been known for some time that an accumulation of excess lipid, including certain sphingolipids, can adversely impact insulin action and glucose metabolism in cells. In this project we will a combination of strategies to test the hypothesis that the sphingolipid profile can be manipulated to have favourable effects on metabolism.

Funding body

National Health and Medical Research Council

Scheme name

Project Grant

Years funded

2017 – 2019

Lead institution

University of NSW

Partner institution

Garvan Institute of Medical Research