Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life.

This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules.

This project aims to study the protein machinery responsible for DNA replication, the process of duplicating genomic information before cell division.

By making real-time single-molecule movies of the replication process, this project aims to unravel the molecular mechanisms of this important process and provide the knowledge required to understand disease mechanisms and catalyse drug development.

Funding body

Australian Research Council 

Scheme name

Australian Laureate Fellowships

Years funded

2014 – 2019

Lead institution

University of Wollongong

Partner institution

University of Groningen (Netherlands)

Project leaders

Research area