Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease, MND) is characterised by rapid paralysis leading to death within two to five years of onset.

There are no effective diagnostic tests or treatments. Confusion remains around the primary cause of paralysis.

We recently discovered ALS gene mutations that disrupt normal nerve function, a process known as abnormal protostasis.

This gives us a unique opportunity to unlock the primary cause of paralysis and develop animal models of ALS.

Funding body

National Health and Medical Research Council

Scheme name

Project Grant

Years funded

2016 – 2018

Lead institution

Macquarie University