Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease, MND) is characterised by rapid paralysis leading to death within 2 to 5 years of onset.

There are no effective diagnostic tests or treatments. Confusion remains around the primary cause of paralysis.

We recently discovered ALS gene mutations that disrupt normal nerve function, a process known as abnormal protostasis. This gives us a unique opportunity to unlock the primary cause of paralysis and develop animal models of ALS.

Funding body

National Health and Medical Research Council

Scheme name

Project Grant

Years funded

2016 – 2018

Lead institution

Macquarie University