Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease, MND) is characterised by rapid paralysis leading to death within 2 to 5 years of onset.
There are no effective diagnostic tests or treatments. Confusion remains around the primary cause of paralysis.
We recently discovered ALS gene mutations that disrupt normal nerve function, a process known as abnormal protostasis. This gives us a unique opportunity to unlock the primary cause of paralysis and develop animal models of ALS.
National Health and Medical Research Council
2016 – 2018