We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime.

A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood.

We will investigate the structure and function of one of these machines that has been strongly linked to cancer.

Funding body

National Health and Medical Research Council

Scheme name

Project Grant

Years funded

2017 – 2021

Lead institution

University of Sydney

Partner institutions

Australian National University; University Of Sydney; Children’s Hospital of Philadelphia (United States Of America)

Research area