Summary

Motor neurons are some of the biggest cells in the human body. Some of these neurons can be up to 1 m in length.

This provides a unique problem: how does a motor neuron maintain homeostasis at the synapse that is 1 m away?

This project aims to characterise how motor neurons solve this unique problem and attempt to link dysfunction in synaptic homeostasis to Motor Neurone Disease (MND) by looking at proteins and genes.

Funding body

Motor Neurone Disease Australia

Scheme name

Betty Laidlaw Prize

Years funded

2018 – 2021

Lead institution

University of Wollongong