Nicotinic receptors are intrinsic membrane proteins that play a role in communication in excitable cells, particularly in the nervous system.

The primary goals of this project are to define the structural and functional determinants of nicotinic-conotoxin interactions at a molecular level, and develop new selective probes that advance neurophysiological research.

The diversity and distribution of nicotinic receptor subtypes being uncovered through molecular biology and selective conotoxin probes presents an exciting opportunity for the discovery of new therapeutic agents.

Funding body

Australian Research Council

Scheme name

Discovery Project

Years funded

2016 – 2019

Lead institution

University of Wollongong

Partner institutions

Hainan University (China); Royal Melbourne Institute of Technology; University Of Queensland