This project aims to develop and use new technologies to address mechanistic aspects of anti-bacterial compounds in development, and of the development of resistance to them.

The project will focus on the sliding clamp subunit of the bacterial replicative polymerase by studying its association with many other proteins in vitro and in vivo, using novel techniques in solid-state NMR, single-molecule fluorescence and molecular microbiology.

The outcomes are expected to be an increased understanding of bacterial DNA replication and mechanisms of antibiotic action and resistance.

This project expects to generate new knowledge to assist in combatting antibiotic resistance in Gram-negative bacterial pathogens

Funding body

Australian Research Council

Scheme name

Discovery Project

Years funded

2018 – 2021

Lead institution

University of Wollongong