Sepsis is a major clinical problem that causes more deaths in Australia than breast, prostate or colon cancer. The deaths result from an overwhelming systemic inflammatory response to infection.
We have discovered that this response is dependent on an enzyme called GSTO1-1 and that inhibitors can block the inflammatory response. In this study we will identify new drug like compounds that can inhibit GSTO1-1 and prevent death from sepsis.
National Health and Medical Research Council
2017 – 2020
Australian National University (ANU)