This project will examine whether overexpression of the FKBP5 gene may create a distinct pattern of gene expression in the brain and body that could be used to identify psychiatric patients who would benefit from drugs that suppress the gene’s activity.
FKBP5 is a key regulator of the stress response. Previous research by Dr. Matosin’s lab indicates that overexpression of the gene is linked to long term changes in cellular and systemic stress levels that may increase the risk of psychiatric illnesses such as depression, bipolar disorder and schizophrenia. (genetics; depression, bipolar disorder, schizophrenia).
Brain & Behaviour Research Foundation
NARSAD Young Investigator
2018 – 2020
University of Wollongong