An understanding of the molecular pathways that lead to Alzheimer’s disease (AD) is urgently required to identify therapeutic targets and develop rational approaches for disease-stalling treatments.
My group is focussing on 3 main projects. Two of these projects deal with ABCA7 and apoE, proteins encoded by genes that top the list for increased AD risk.
The third project focuses on our new findings that link impaired lysosomal function with defective vitamin B12 utilisation in AD and other age-related conditions.
National Health and Medical Research Council
2016 – 2020
University of Wollongong