Summary

New human cell culture models of Alzheimer’s disease are urgently needed to help translate drugs into successful patient outcomes.

In this proposal we will develop an Alzheimer’s disease brain-on-a-chip that contains the major human brain cell types and neuropathological features of the Alzheimer’s.

We will demonstrate the applicability of the model for identifying new Alzheimer’s disease drugs and diagnostics and show that the model can be readily adopted by Australian Alzheimer’s researchers.

Funding body

National Health and Medical Research Council

Scheme name

Project Grant

Years funded

2017 – 2019

Lead institution

QIMR Berghofer Medical Research Institute

Partner institution

University of Melbourne