This project aims to understand why motor neurons are specifically vulnerable in MND.

The electrical properties of motor neurons change even before symptom onset. The reasons behind this are unknown but since this is common to familial and sporadic MND, these mechanisms are likely important in disease onset and progression.

We will investigate how and why the properties of motor neurons change before, during and after disease onset and the role of astrocytes, cells that normally perform a supportive role for neurons, in contributing to these changes and neuronal death in MND. Identifying these pathways may lead to a novel treatment avenue.

Funding body

Motor Neurone Disease Australia

Scheme name


Years funded


Lead institution

University of Wollongong