Testing new treatments, drugs and devices

IHMRI’s well-equipped Clinical Research and Trials Unit (CRTU) offers facilities and services for a range of clinical research studies and commercial clinical trials. Our region’s stable and accessible population base, which is set to grow to over 465,172 by 2036 (Wollongong City, Shellharbour City and Shoalhaven City Councils), demographic and economic diversity, and incidence of chronic disease, makes it ideal for population health studies and clinical trials. Read more about our region. To see the range of equipment and services available visit Assistance with clinical trials. Members of the community who are interested in taking part in clinical trials can read more at Participate in clinical trials.

Current clinical trials

There are a number of both commercial and investigator initiated clinical trials that are conducted in the CRTU.  The CRTU supports a number of researchers from the UOW’s School of Medicine.  Research from the School of Medicines, Smart Food Centre led by Professor Karen Charlton, the Medical and Exercise Science Department led by Dr Monique Francois, and from clinical psychologist Dr Susan Thomas, are all supported by the IHMRI CRTU. The CRTU is also home to the Australian Centre for Electromagnetic Bioeffects Research, led by Senior Professor Rodney Croft, which conducts a range of clinical trials, both in the dedicated sleep study rooms and in the faraday cage.  These studies are currently on hold, but will be posted on this site when they start up again in the near future.

Now recruiting 

Symbiotic Study: SYMptom, microBIOme and dieT in Chronic Kidney disease. A new renal diet designed to improve gut health, diet quality and other clinical outcomes for patients with chronic kidney disease now recruiting  If you:

  • Are over 18 years of age
  • Have been diagnosed with stage 3 CKD (eGFR 30-59ml/min per 1.73m2)

Then you may be eligible for this study.  If you are interested in finding out more, then please click on the now recruiting link to register your interest    

Vitamin D and Bone Health Study in Australian Women A landmark study looking at what determines vitamin D status in women by reviewing skin type latitude, diet, and sun exposure now recruiting If you:

  • Are over 18 years of age
  • Are a woman
  • Are pre-menopausal or post-menopausal

Then you may be eligible for this study.  If you are interested in finding out more, then please click on the now recruiting link to register your interest    

GDM Supper Study  a national study investigating whether consuming a snack 30 minutes prior to bed is a viable treatment option to improve fasting glucose levels in women with gestational diabetes mellitus (GDM)  – now recruiting If you:

  • Are pregnant and diagnosed with GDM, less than 30 week gestation
  • Singleton pregnancy 

  Preventing cardiovascular disease in people with type 2 diabetes:  When is the best time to move? This project seeks to determine the feasibility and effectiveness of timing exercise to control blood glucose levels and reduce cardiovascular risk in people with Type 2 Diabetes  – now recruiting If you:

  • Are aged between 40 and 75 years
  • Have a BMI between 27-40kg/ m2
  • HbA1c between 6.5-9.0%
  • Have diabetes treated with lifestyle, oral medications and/or intermediate/long acting inslin
  • Stable weight for previous 3 months (+ 4kgs)
  • Stable medications for previous 3 months

Then you may be eligible for this study.  If you are interested in finding out more, then please click on the now recruiting link to register your interest    

Protecting your arteries: When is the right time to move? A study to test whether the timing of exercise prescription in relation to a glucose-challenge will alter vascular responses and therefore cardiovascular risk If you:

  • Are aged between 25-40 years
  • Have a stable weight for past 3 months (­­+ 4kgs)

Then you may be eligible for this study.  If you are interested in finding out more, then please click on the now recruiting link to register your interest    

Hormones as indicators of personality and mental wellbeing – a study that measures hormones such as testosterone, oxytocin, dopamine and cortisol against individuals’ personality traits  – now recruiting If you:

  • Are 18 years of age
  • Are not taking psychoactive medications
  • Do not have a neurological condition

Then you may be eligible for this study.  If you are interested in finding out more, then please click on the now recruiting link to register your interest    

ColoSTAT ™️: A simple low cost blood test for the early detection of colorectal cancer.  Developed over 13 years of research by the CSIRO and now being trialled by Rhythm Biosciences – now recruiting If you:

  • are aged 40 < 85
  • are having a colonoscopy in the next 3 months  

Then you may be eligible for this study.  If you are interested in finding out more, then please click on the now recruiting link to register your interest

Trials opening soon

Cannabidoil: Treatment of brain repair and depression in early-stage dementia  If you:

  • Are aged between 45 and 65 years
  • A doctor has confirmed that you have early stage dementia

Then you may be eligible for this study.  If you are interested in finding out more, then please click on the now recruiting link to register your interest     Medical Device Trial:  CENOFEX Smart Devices for the Management of Lympheodema: Pilot Feasibility Study If you:

  • Are over 18 years of age
  • Have confirmed lymphoedema
  • Your general health is satisfactory

Then you may be eligible for this study. If you are interested in finding out more, then please click on the now recruiting link to register your interest  

Trials in follow up

  • Shingles Vaccine: Zoster 049 study. A long running trial involving 31,000 people in 18 countries.  Recruitment closed
  • Myovant SPIRIT EXTENSION study: An extension of the SPIRIT 2 study for women with Endometriosis-Associated Pain. Recruitment closed
  • CLEAR – Cardiovascular Study: A study assessing the effects of a new drug on the occurrence of major cardiovascular events in patients who are statin intolerant. Recruitment closed

Supported trials 

The CRTU staff also assist UOW Researchers with their clinical trials by offering their professional services. These Researchers include:

  • Professor Marie Ranson/Senior Research Fellow Kara Perrow – Plasma enzymes as a source of cellular invasive potential
  • Dr Carolyn Dillon – Development of novel therapeutics for the treatment of cancer
  • Professor Ronald Sluyter – In Vitro studies/humanised mice experiments

Past clinical trials

  • Asthma medication study: Using existing medication in a new way to see if asthma management can be improved
  • Over Active Bladder (OAB): Testing safety and tolerability of a new combination of drugs to improve the symptoms of OAB.
  • COMPOSE: A clinical study to assess the safety and potential efficacy of a compound to improve memory, language and learning in people with Down Syndrome.
  • Obesity study: A placebo-controlled weight loss study of an investigational medication.
  • Osteoarthritis study: Assessing the effectiveness of a new drug to relieve pain.
  • Gout study: An evaluation of an investigational drug to see whether, when combined with allopurinol, it reduces high uric acid levels in the blood.
  • Cold sores: Testing an investigational mouth wash to reduce duration of cold sore episodes.
  • Shingles vaccine: A long-running trial involving 31,000 people in 18 countries (the vaccine was shown to be 97 per cent successful in protecting older people from shingles, as reported to the New England Journal of Medicine).
  • Myovant SPIRIT 2 Study: An International Phase 3 Randomised, Double-Blind, Placebo-Controlled Efficacy and Safety Study of a new drug for women with Endometriosis-Associated Pain.
  • Queen Garnet Plum Juice: A randomised controlled trial evaluating the effects of fruit derived anthocyanins for mild cognitive impairment
  • Mood, Food and Biomarkers Study: This trial is looking at the correlation between hormone levels and the behaviours and symptoms of depression
  • DUPLEX – Renal Study: A randomised, multicentre, double blind, parallel, active control study of a new drug for patients with Primary focal Segmental Glomerulosclerosis (FSGS).

In the news

Contacts

Clinical Director

A/Professor Bruce Ashford

E: bruceash@uow.edu.au 

C

Clinical Research Program Coordinator Julie Ferguson RN T: +61 2 4221 5951 E: fjulie@uow.edu.au

c

Senior Clinical Trials Coordinator Kim Bloomfield T: +61 2 4221 5517 E: bloomfie@uow.edu.au